CBD cosmetics and acne/seborrheic skin.
The popularity of CBD oils is not difficult to notice, the same applies to dried CBD, as well as prolls, i.e. so-called. cannabis joints. However, it is also getting louder about cosmetics with CBD, which are flagged by manufacturers with slogans such as: perfect for sensitive, dry or seborrheic skin, precisely due to the presence of cannabidiol. In this post, we will quote a study on the properties of CBD contained in cosmetics for skin with acne and seborrheic problems. Are there relevant studies that support this? Is it really worth buying cosmetics from cannabidiol?
Why CBD in cosmetics for acne and seborrheic skin?
Despite many studies, there are still no drugs that would effectively deal with many pathogenetic factors associated with the occurrence of acne, i.e. with overproduction of sebum, with undesirable proliferation of seborrheic cells (sebocytes), and with inflammation.[1] The same applies to effective cosmetics.
According to previous research on the endocannabinoid system functioning in the human body, it is involved in the regulation of various physiological processes. The elements of the EKAN system are also found in the human skin and this fact is important when it comes to the therapeutic properties of the phytocannabinoid - CBD, in the case of disorders occurring in the skin.
The EKAN system in the skin regulates the growth and differentiation of its cells and also has an anti-inflammatory effect ([2]). Thanks to this, cannabinoids can both inhibit and activate various processes in the skin. This is the basis of the entire regulatory function performed by the endocannabinoid system. Cannabinoids can inhibit or activate the production of sebum and the formation of inflammation ([3]).
What is the impact of the plant cannabinoid, which is cannabidiol - CBD, on the processes taking place in the skin related to such disorders as excessive sebum production or the formation of inflammation?
There is an in vitro study on the effects of CBD on the sebaceous glands. This study used human immortalized sebaceous cells (SZ95 ) [1] and the full-thickness human skin organ culture (hSOC) technique to further replicate in vivo (living organism) conditions. It turned out that CBD, among others regulates excessive lipid synthesis of human sebaceous cells induced by "pro-acne agent" (Figure 1-C, Figure 1-E)

Figure 1, C - quantitative determination of lipids with the Nile red reagent - PL - polar lipids, NL - neutral lipids, AEA - prototype ananamide - an endocannabinoid that induces sebum production. [1]

Figure 1 (A, B, D and E) Semi-quantitative lipid synthesis assay for (A) control, (B) 10 μM CBD, (D) 30 μM AEA and (E) 30 μM AEA plus 10 μM CBD. [1]
The study also tested the effect of cannabidiol on the effects of other lipogenic substances, which, as previously shown, act through various, independent of the EKAN signaling mechanisms. Indeed, CBD effectively inhibited lipid synthesis induced by arachidonic acid (AA) or the combination of linoleic acid and testosterone (LA-T) (Figure 2). So it turned out that CBD does not only act on the pathways of the endocannabinoid system, but has a general, universal lipostatic effect.

Figure 2 Percentage of lipid synthesis after adding AA - arachidonic acid, LA - linoleic acid, T - testosterone and CBD. The solid line marks 100%, i.e. the value corresponding to the control sample. [1]

Figure 3 (A) Sebocyte proliferation after 72h. The solid line indicates cell level in the control group after 24h. (B) Sebocyte viability after 24h. (C) Cell necrosis and apoptosis after 24h.[1]

Figure 3 hSOC - full thickness skin after 14 days (D) control (E) 10 μM CBD, (F) 30 μM AEA, and (G) 30 μM AEA plus 10 μM CBD. [1]

Figure 4 Effect of CBD on TNFA expression induced by anti-acne agents LA, LTA.
Also in this topic, CBD does not disappoint. The study showed that CBD exerted universal anti-inflammatory effects. In addition, it has been shown that cannabiodiol also prevents the expression of TNFA (TNFA - cytokines associated with inflammatory processes - a key cytokine in the pathogenesis of acne vulgaris) caused by pro-acne compounds: LA-T, (Figure 4). The collected data suggest that CBD may exert an anti-inflammatory effect on human sebocytes.
In conclusion, due to its demonstrated potential lipostatic, anti-proliferative and anti-inflammatory effects, CBD has potential as a promising therapeutic agent in the treatment of acne vulgaris.
The cited study was not conducted on humans, but only on human cells, in laboratory conditions. This is, among other things, because it can only testify to the potential therapeutic properties of CBD in the treatment of acne and seborrheic skin. Nevertheless, there is considerable evidence that CBD may also act as a potent anti-acne agent in vivo when tested in appropriate clinical trials.
Cosmetics with CBD, is it worth it?
Certainly, as with all other cosmetics, there is no perfect preparation that will be suitable for every person. Probably not one person, after a friend recommended an amazing cream that helped her get rid of all skin problems, was completely disappointed (with the same cosmetic). Each body is different, but a good product will definitely be liked by more people than the bad one. Products with the same composition can be completely different, e.g. due to the origin of these ingredients. The same can be true of cannabidiol. CBD used in cosmetics from different manufacturers may be of different purity and/or origin. In our store, we have selected cosmetics with CBD that we think deserve attention. Answering the question of whether CBD cosmetics will be good for your skin? Will they surprise you positively or negatively? You will surely get the best answer from your own skin. Therefore, if you ask yourself such a question, just try cosmetics with cannabiodiol and form your own opinion.