CBD cosmetics and acne/seborrheic skin.

The popularity of CBD oils is not difficult to notice, the same applies to dried CBD, as well as prolls, i.e. so-called. cannabis joints. However, it is also getting louder about cosmetics with CBD, which are flagged by manufacturers with slogans such as: perfect for sensitive, dry or seborrheic skin, precisely due to the presence of cannabidiol. In this post, we will quote a study on the properties of CBD contained in cosmetics for skin with acne and seborrheic problems. Are there relevant studies that support this? Is it really worth buying cosmetics fromacne 6107540 1280 cannabidiol?

Why CBD in cosmetics for acne and seborrheic skin?

Despite many studies, there are still no drugs that would effectively deal with many pathogenetic factors associated with the occurrence of acne, i.e. with overproduction of sebum, with undesirable proliferation of seborrheic cells (sebocytes), and with inflammation.[1] The same applies to effective cosmetics.

According to previous research on the endocannabinoid system functioning in the human body, it is involved in the regulation of various physiological processes. The elements of the EKAN system are also found in the human skin and this fact is important when it comes to the therapeutic properties of the phytocannabinoid - CBD, in the case of disorders occurring in the skin.

The EKAN system in the skin regulates the growth and differentiation of its cells and also has an anti-inflammatory effect ([2]). Thanks to this, cannabinoids can both inhibit and activate various processes in the skin. This is the basis of the entire regulatory function performed by the endocannabinoid system. Cannabinoids can inhibit or activate the production of sebum and the formation of inflammation ([3]).

What is the impact of the plant cannabinoid, which is cannabidiol - CBD, on the processes taking place in the skin related to such disorders as excessive sebum production or the formation of inflammation?

There is an in vitro study on the effects of CBD on the sebaceous glands. This study used human immortalized sebaceous cells (SZ95 ) [1] and the full-thickness human skin organ culture (hSOC) technique to further replicate in vivo (living organism) conditions. It turned out that CBD, among others regulates excessive lipid synthesis of human sebaceous cells induced by "pro-acne agent" (Figure 1-C, Figure 1-E)

Figure 2 CBD and lipid synthesis in the skin

Figure 1, C - quantitative determination of lipids with the Nile red reagent - PL - polar lipids, NL - neutral lipids, AEA - prototype ananamide - an endocannabinoid that induces sebum production. [1]

The effect of CBD on the lipogenesis (sebum production) of sebocytes was also assessed, both after 24 hours of treatment and after 48 hours. No effect of cannabidiol on basal lipogenesis of sebaceous cells was observed – sebocytes (Figure 1, C).

CBD cosmetics for oily skin

Figure 1 (A, B, D and E) Semi-quantitative lipid synthesis assay for (A) control, (B) 10 μM CBD, (D) 30 μM AEA and (E) 30 μM AEA plus 10 μM CBD. [1]

It is known that endocannabinoids contained in the human body have an intense lipogenic effect by affecting CB2 receptors. When additional amounts of the prototype endocannabinoid AEA, Ananamide, were administered, CBD significantly inhibited its lipogenic effects in a dose-dependent manner (Figure 1-C). That is, a possible disorder related to the presence of too much natural endocannabinoids, which could be stimulated by various factors, substances or other disorders in the body, could be inhibited, regulated by CBD - a plant cannabinoid. Thus, the body would not be forced to excessive sebum production in the skin, which manifests itself, among others, in acne. blemishes and acne.

The study also tested the effect of cannabidiol on the effects of other lipogenic substances, which, as previously shown, act through various, independent of the EKAN signaling mechanisms. Indeed, CBD effectively inhibited lipid synthesis induced by arachidonic acid (AA) or the combination of linoleic acid and testosterone (LA-T) (Figure 2). So it turned out that CBD does not only act on the pathways of the endocannabinoid system, but has a general, universal lipostatic effect.

Figure 2 oily skin CBD cosmetics

Figure 2 Percentage of lipid synthesis after adding AA - arachidonic acid, LA - linoleic acid, T - testosterone and CBD. The solid line marks 100%, i.e. the value corresponding to the control sample. [1]

The effect of CBD on the proliferation of sebaceous cells has also been studied, which is another important thing when it comes to the effectiveness of anti-acne remedies. It turned out that CBD reduces the proliferation but not the viability of human sebaceous cells (Figure 3) both in vitro and ex vivo (in a study on living tissues performed outside the body). Due to the fact that CBD did not reduce the number of sebocytes below the baseline value (Figure 3-B), but only inhibited their proliferation (Figure 3 - A, G), cannabidiol appears to have a pure anti-proliferative effect. Tested concentrations of CBD did not reduce cell viability or induce apoptosis or necrosis of SZ95 sebocytes (Figure 3 – B, C).

Figure 3 acne skin2 CBD

Figure 3 (A) Sebocyte proliferation after 72h. The solid line indicates cell level in the control group after 24h. (B) Sebocyte viability after 24h. (C) Cell necrosis and apoptosis after 24h.[1]

Figure 4 acne skin and CBD

Figure 3 hSOC - full thickness skin after 14 days (D) control (E) 10 μM CBD, (F) 30 μM AEA, and (G) 30 μM AEA plus 10 μM CBD. [1]

Another desirable feature of cosmetics for acne and oily skin would be their anti-inflammatory properties.

picture 4 CBD cosmetics seborrheic skin 1

Figure 4 Effect of CBD on TNFA expression induced by anti-acne agents LA, LTA.

Also in this topic, CBD does not disappoint. The study showed that CBD exerted universal anti-inflammatory effects. In addition, it has been shown that cannabiodiol also prevents the expression of TNFA (TNFA - cytokines associated with inflammatory processes - a key cytokine in the pathogenesis of acne vulgaris) caused by pro-acne compounds: LA-T, (Figure 4). The collected data suggest that CBD may exert an anti-inflammatory effect on human sebocytes.

In conclusion, due to its demonstrated potential lipostatic, anti-proliferative and anti-inflammatory effects, CBD has potential as a promising therapeutic agent in the treatment of acne vulgaris.

The cited study was not conducted on humans, but only on human cells, in laboratory conditions. This is, among other things, because it can only testify to the potential therapeutic properties of CBD in the treatment of acne and seborrheic skin. Nevertheless, there is considerable evidence that CBD may also act as a potent anti-acne agent in vivo when tested in appropriate clinical trials.

Cosmetics with CBD, is it worth it?

Certainly, as with all other cosmetics, there is no perfect preparation that will be suitable for every person. Probably not one person, after a friend recommended an amazing cream that helped her get rid of all skin problems, was completely disappointed (with the same cosmetic). Each body is different, but a good product will definitely be liked by more people than the bad one. Products with the same composition can be completely different, e.g. due to the origin of these ingredients. The same can be true of cannabidiol. CBD used in cosmetics from different manufacturers may be of different purity and/or origin. In our store, we have selected cosmetics with CBD that we think deserve attention. Answering the question of whether CBD cosmetics will be good for your skin? Will they surprise you positively or negatively? You will surely get the best answer from your own skin. Therefore, if you ask yourself such a question, just try cosmetics with cannabiodiol and form your own opinion.

We invite you to check the products we recommend KLIK

[1] Oláh A, Tóth BI, Borbíró I, et al. Cannabidiol has a sebostatic and anti-inflammatory effect on human sebaceous cells. J Clin Invest . 2014;124(9):3713-3724. doi: 10,1172/JCI64628
[2] Karsak M, et al. Attenuation of allergic contact dermatitis through the endocannabinoid system. Science. 2007;316(5830):1494–149
[3]  Hashim PW, Cohen JL, Pompeii DT, et al. Topical cannabinoids in dermatology. Cutis 2017;100:50-52

Leave a comment

Leave a comment